TLS Online TPP Program

#Id: 1622

#Unit 4. Cell Communication and Cell Signaling

IFN-α or -β activates IFNAR to recruit and activate specific JAKs (JAK1 and Tyk2), which then activate specific STATs induce expression of three genes, Protein kinase R (PKR), which inhibits viral (and cellular) protein synthesis by inhibiting the elongation factor eIF2α; 2’,5’-oligoadenlyate A synthetase, which activates the ribonuclease RNase L that degrades viral mRNA; and Mx proteins, which inhibit both the transcription of viral genes into mRNAs and the assembly of virus particles.

TLS Online TPP Program

#Id: 1623

#Unit 4. Cell Communication and Cell Signaling

Defensins (α and β) Disrupt membranes of bacteria, fungi, protozoan.

TLS Online TPP Program

#Id: 1624

#Unit 4. Cell Communication and Cell Signaling

Lactoferrin Binds and sequesters iron, limiting growth of bacteria and fungi.

TLS Online TPP Program

#Id: 1625

#Unit 4. Cell Communication and Cell Signaling

Surfactant proteins SP-A, SP-D Block bacterial surface components; promotes phagocytosis.

TLS Online TPP Program

#Id: 1626

#Unit 4. Cell Communication and Cell Signaling

calprotectin Binds and sequesters divalent cations, limiting growth of bacteria and fungi.

TLS Online TPP Program

#Id: 1627

#Unit 4. Cell Communication and Cell Signaling

Psoriasin Binds and sequesters divalent cations