#Id: 5918
#Unit 3. Fundamental Processes
The holoenzyme assembles on replication fork DNA in three stages:
1. First the clamp loader uses hydrolysis of ATP to bind b subunits to a template primer complex.
2. Binding to DNA changes the conformation of the site on b that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase
3. A t dimer binds to the core polymerase, and provides a dimerization function that binds a second core polymerase
