ACTH stimulates the synthesis and secretion of cortisol by the activation of adenylyl cyclase via Gs.

TLS Online TPP Program

#Id: 10470

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10471

#Unit 4. Cell Communication and Cell Signaling

A mutation, valine to glutamine in the TM region of the HER2 receptor causes dimerization of the receptor, even in the absence of the ligand, transforming it into the oncoprotein NEU, a constitutively active protein tyrosine kinase.

TLS Online TPP Program

#Id: 10472

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10473

#Unit 4. Cell Communication and Cell Signaling

Deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor leads, to

constitutive activation of the kinase activity of the resulting oncoprotein, ErbB.

TLS Online TPP Program

#Id: 10474

#Unit 4. Cell Communication and Cell Signaling

A point mutation substitutes any other amino acid

for the glycine12 in the Ras, the normal protein is converted into a constitutively active oncoprotein

TLS Online TPP Program

#Id: 10475

#Unit 4. Cell Communication and Cell Signaling

Ras-GAP protein, 

NF1 (neurofibromatosis)