There are 4 genes (I, Z, Y, A), 2 Promoters and 3 lac operators in Lac operon

The major O1 lac operator lies adjacent to promoter

The O1 operator extends from position -5 just upstream of the mRNA start point to position +21 within the transcription unit.

TLS Online TPP Program

#Id: 8197

#Unit 2. Cellular Organization

Zellweger syndrome

Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.

TLS Online TPP Program

#Id: 8198

#Unit 2. Cellular Organization

Lysosomes are membrane-enclosed organelles filled with soluble hydrolytic enzymes that digest macromolecules.

TLS Online TPP Program

#Id: 8199

#Unit 2. Cellular Organization

Lysosomes contain about 40 types of hydrolytic enzymes, All are acid hydrolases, work best at acidic pH including: proteases, nucleases, glycosidases, lipases, phospholipases, phosphatases, and sulfatases.

TLS Online TPP Program

#Id: 8200

#Unit 2. Cellular Organization

For optimal activity, of acid hydrolases they need to be: Activated by proteolytic cleavage Requires an acid environment.

TLS Online TPP Program

#Id: 8201

#Unit 2. Cellular Organization

Lysosome an interior pH of about 4.5–5.0

TLS Online TPP Program

#Id: 8202

#Unit 2. Cellular Organization

Most of the lysosome membrane proteins, are highly glycosylated, which helps to protect them from the lysosome proteases