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TLS Online TPP Program

#Id: 435

The nucleosome consists of approximately equal masses of DNA and histones (including H1). The predicted mass of the nucleosome is 262 kD.


#Unit 2. Cellular Organization #Octamer & Nucleosome #Part B Pointers
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TLS Online TPP Program

#Id: 7790

#Unit 2. Cellular Organization

Nuclear transport receptor
have affinity for FG-repeats on nucleoporins.
TLS Online TPP Program

#Id: 7791

#Unit 2. Cellular Organization

The mechanism for the import of cytoplasmic cargo proteins mediated by a nuclear transport receptor known as importin.
TLS Online TPP Program

#Id: 7792

#Unit 2. Cellular Organization

Ran is a small monomeric G protein
That exists in either a GTP-bound or a GDP-bound conformation & provides the energy to drive unidirectional transport of macromolecules through the nuclear pore.
TLS Online TPP Program

#Id: 7793

#Unit 2. Cellular Organization

Nuclear-export signal (NES)

ribonuclear protein complexes that shuttle between the nucleus and the cytoplasm. Such shuttling proteins contain NES.
TLS Online TPP Program

#Id: 7794

#Unit 2. Cellular Organization

Shuttling protein have identified at least three different types of NESs: 
A. A leucine-rich sequence found in PKI 
B. In the Rev protein of human immunodeficiency virus (HIV)
C. In two heterogeneous ribonucleoprotein particles (hnRNPs)
TLS Online TPP Program

#Id: 7795

#Unit 2. Cellular Organization

Nuclear export mechanism are of two types:

Ran-dependent nuclear export

Ran-independent nuclear export