ATP is required for the binding, but is not hydrolyzed until a later stage. The transcription factor ABF1 binds to the B3 element; this assists initiation by affecting chromatin structure, but it is the events that occur at the A and B1 elements that actually cause initiation

TLS Online TPP Program

#Id: 10003

#Unit 4. Cell Communication and Cell Signaling

Mice homozygous for a null allele of dhh exhibit defective spermatogenesis

TLS Online TPP Program

#Id: 10004

#Unit 4. Cell Communication and Cell Signaling

Indian hedgehog is expressed in the gut and cartilage and is important in postnatal bone growth

TLS Online TPP Program

#Id: 10005

#Unit 4. Cell Communication and Cell Signaling

Sonic hedgehog is responsible for assuring that motor neurons come only from the ventral portion of the neural tube & essential for normal patterning of the limbs

TLS Online TPP Program

#Id: 10006

#Unit 4. Cell Communication and Cell Signaling

Hedgehog protein with autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion.

TLS Online TPP Program

#Id: 10007

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10008

#Unit 4. Cell Communication and Cell Signaling

The freed C-terminal is not involved in signaling and is often degraded, whereas the N-terminal becomes the active Hedgehog protein intended for secretion