As the transition from G1 to S phase begins, CDK/cyclins recruit cdc45 and the GINS complex to the MCM helicase, which then becomes known as the CMG complex (Cdc45-MCM-GINS)

#Id: 8218

#Unit 2. Cellular Organization

Sorting signal that directs lysosomal hydrolases from the TGN to the late endosome is- Mannose 6-phosphate (M6P).

#Id: 8219

#Unit 2. Cellular Organization

1. N-acetylglucosamine (GlcNAc) phosphotransferase
2. Phosphodiesterase

#Id: 8221

#Unit 2. Cellular Organization

#Id: 8223

#Unit 2. Cellular Organization

#Id: 8224

#Unit 2. Cellular Organization

#Id: 8225

#Unit 2. Cellular Organization

Hurler’s disease- mutation in a structural gene that codes for an individual lysosomal hydrolase.