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An additional DNA element that binds RNA polymerase is found in some strong promoters, for example, those directing expression of the ribosomal RNA (rRNA) genes. This is called an UP-element and increases polymerase binding by providing an additional specific interaction between the enzyme and the DNA.


#Unit 3. Fundamental Processes #Prokaryotic Transcription #Part B Pointers
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#Unit 8. Inheritance Biology

Segmental duplications have played an important role in the evolution of human chromosomes; about 4% of the human genome consists of segmental duplications. 


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#Unit 8. Inheritance Biology

Unbalanced gene dosage leads to developmental abnormalities.


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#Unit 8. Inheritance Biology

Chromosome deletion 

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#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

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#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion
ntercalary/interstitial deletion 
Microdeletion

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#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm
Wolf– Hirschhorn syndrome- Deletion on 4, short arm
Williams– Beuren syndrome - Deletion on 7, long arm
Prader– Willi syndrome- Deletion on 15 long arm 

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