Model of Intrinsic Termination

Bacterial terminators act by:

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#Unit 7. System Physiology – Animal

SS14 & SS28 both inhibits the secretion of insulin, glucagon, and pancreatic polypeptide and act locally within the pancreatic islets in a paracrine fashion

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#Unit 7. System Physiology – Animal

Human pancreatic polypeptide contains 36 amino acid residues and is produced by F cells in the islets

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#Unit 7. System Physiology – Animal

Pancreatic polypeptide is closely related to, 

polypeptide YY, a gastrointestinal peptide

neuropeptide Y, found in the brain & autonomic nervous system

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#Unit 7. System Physiology – Animal

In the normal male fetus,  the wolffian duct system on each side develops into the epididymis and vas deferens

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#Unit 7. System Physiology – Animal

The Y chromosome is necessary and sufficient for the production of testes, and the testis-determining gene product is called SRY (for sex-determining region of the Y chromosome)

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#Unit 7. System Physiology – Animal

SRY is a DNA-binding regulatory Protein, bends the DNA & acts as a transcription factor that initiates transcription of a cascade of genes necessary for testicular differentiation