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TLS Online TPP Program

#Id: 6393

The E. coli trp operon contains the 5 genes Trp-EDCBA for the anabolic enzymes to make the tryptophan.

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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TLS Online TPP Program

#Id: 8341

#Unit 2. Cellular Organization

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks
TLS Online TPP Program

#Id: 8342

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8343

#Unit 2. Cellular Organization

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly
TLS Online TPP Program

#Id: 8345

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8346

#Unit 2. Cellular Organization

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase
TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)