Autosomal Recessive Traits

Autosomal recessive traits normally appear with equal frequency in both sexes.

The trait seems to skip generations.

When both parents are heterozygous, approximately one-fourth of the offspring are expected to express the trait.

Recessive traits appear more frequently among the offspring of consanguineous matings.

Example - Tay–Sachs disease, sickle cell anemia, cystic fibrosis, PKU

TLS Online TPP Program

#Id: 6477

#Unit 3. Fundamental Processes

Start point, is the first base of mRNA to be A Initiator (Inr) is Py2CAPy5, where Py stands for any pyrimidine. The Inr is contained between positions -3 and +5. TATA box, usually located, 25 bp upstream in its location at -25

TLS Online TPP Program

#Id: 6478

#Unit 3. Fundamental Processes

Promoters that do not contain a TATA element are called TATA-less promoters. Surveys of promoter sequences suggest that 50% or more of promoters may be TATA-less.

TLS Online TPP Program

#Id: 6479

#Unit 3. Fundamental Processes

Constitutive active housekeeping genes and developmentally regulated genes have TATA-less promoters 

TLS Online TPP Program

#Id: 6480

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6481

#Unit 3. Fundamental Processes

TATA less, Inr Less promoters uses Sp1 activator to position TBP with TAFs

TLS Online TPP Program

#Id: 6482

#Unit 3. Fundamental Processes

Sp1 contains three zinc fingers, 25% of their amino acid residues are Gln