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TLS Online TPP Program

#Id: 6458

Two commonly used epitope tags are FLAG, which encodes the amino acid sequence DYKDDDDK (single-letter amino acid code), and myc, which encodes the sequence EQKLISEEDL.



#Unit 3. Fundamental Processes #Eukaryotic Transcription #Part B Pointers
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TLS Online TPP Program

#Id: 8649

#Unit 2. Cellular Organization

During S phase and mitosis, 
Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.
TLS Online TPP Program

#Id: 8650

#Unit 2. Cellular Organization

G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition
TLS Online TPP Program

#Id: 8651

#Unit 2. Cellular Organization

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1
TLS Online TPP Program

#Id: 8652

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8653

#Unit 2. Cellular Organization

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.
TLS Online TPP Program

#Id: 8654

#Unit 2. Cellular Organization

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase