Removal of insulin, the plasma membrane GLUT4 is internalized by endocytosis and eventually transported to GSVs

TLS Online TPP Program

#Id: 6561

#Unit 7. System Physiology – Animal

GLP-1 is processed further by removal of its amino-terminal amino acid residues and the product, GLP-1 (7–36), is a potent stimulator of insulin secretion

TLS Online TPP Program

#Id: 6562

#Unit 7. System Physiology – Animal

Glucagon is glycogenolytic, gluconeogenic, lipolytic, and ketogenic

TLS Online TPP Program

#Id: 6563

#Unit 7. System Physiology – Animal

The glucagon receptor, found primarily on liver cells, is coupled to the Gαs protein, to activate adenylyl cyclase and increase intracellular cAMP

TLS Online TPP Program

#Id: 6564

#Unit 7. System Physiology – Animal

The binding of glucagon to its receptor, leading to activation of protein kinase A, which inhibits glycogen synthesis and promotes glycogenolysis

TLS Online TPP Program

#Id: 6565

#Unit 7. System Physiology – Animal

TLS Online TPP Program

#Id: 6566

#Unit 7. System Physiology – Animal

Glucagon receptors located on the same hepatic cells to activate phospholipase C, and the resulting increase in cytoplasmic Ca2+ also stimulates glycogenolysis