Prp5 is critical for U2 binding

Brr2 facilitates U1 and U4 release

Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome

TLS Online TPP Program

#Id: 10313

#Unit 4. Cell Communication and Cell Signaling

The Immune system is a second line of defense against cancer formation

TLS Online TPP Program

#Id: 10314

#Unit 4. Cell Communication and Cell Signaling

Tumors that arise from exposure to mutagens, such as melanomas (UV light) and lung carcinomas (tobacco smoke) the number of mutations may be hundredfold greater than this. These altered proteins are known as neo-antigens

TLS Online TPP Program

#Id: 10315

#Unit 4. Cell Communication and Cell Signaling

Cancer cells influence the behavior of the fibroblasts and immune cells.

TLS Online TPP Program

#Id: 10316

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10317

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T Cells target tumor cells

Most tumor cells, express MHC class I molecules on their surface, cytotoxic T cells can directly recognize them. 

cytotoxic T cells can result in killing of the tumor cells by two different mechanisms

TLS Online TPP Program

#Id: 10318

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T cells release granules containing the proteins perforin and granzyme-B.