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TLS Online TPP Program

#Id: 6676

Prp5 is critical for U2 binding
Brr2 facilitates U1 and U4 release
Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome

#Unit 3. Fundamental Processes #Capping, Polyadenylation, Splicing and Alternative splicing #Part B Pointers
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TLS Online TPP Program

#Id: 8519

#Unit 2. Cellular Organization


TLS Online TPP Program

#Id: 8520

#Unit 2. Cellular Organization

Post-translational modifications of tubulin:
Lysine acetylation
Detyrosylation
Polyglutamylation
Polyglycylation
TLS Online TPP Program

#Id: 8521

#Unit 2. Cellular Organization

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.
TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 
ε-amino group of a specific lysine of α-tubulin
Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)
TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8524

#Unit 2. Cellular Organization

Detyrosylation 
tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits.