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TLS Online TPP Program

#Id: 6685

Steric Hindrance and Combinations of Major and Minor Splice Sites are major reasons behind alternative splicing (Mutually Exclusive Splicing) 

#Unit 3. Fundamental Processes #Capping, Polyadenylation, Splicing and Alternative splicing #Part B Pointers
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TLS Online TPP Program

#Id: 10459

#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.
TLS Online TPP Program

#Id: 10460

#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma
translocation between chromosomes 8 and 14
TLS Online TPP Program

#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 
MYC is translocated close to an antibody gene, leading to overproduction of MYC
TLS Online TPP Program

#Id: 10462

#Unit 4. Cell Communication and Cell Signaling

MYC gene encodes a basic helix-loop-helix protein
include MAD, MAX, and MNT
TLS Online TPP Program

#Id: 10463

#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.
TLS Online TPP Program

#Id: 10464

#Unit 4. Cell Communication and Cell Signaling

MAD and MNT work with the SIN3 co-repressor protein to bring in histone deacetylases that help to block transcription