Dicer will act on any dsRNA, regardless of sequence, and will cleave this molecule 22 nucleotides from its end.  The PAZ domain anchors the 3’ terminus of the substrate RNA to position the active sites of the enzyme 22 nucleotides away in a ruler-like fashion

TLS Online TPP Program

#Id: 1532

#Unit 2. Cellular Organization

The activity of the MAPs is regulated by the reversible phosphorylation of their projection domains.

TLS Online TPP Program

#Id: 1533

#Unit 2. Cellular Organization

Microtubule-affinity regulating kinase (MARK/Par-1) is a key modulator of tau proteins. 

TLS Online TPP Program

#Id: 1534

#Unit 2. Cellular Organization

MAP4, are phosphorylated by a cyclin-dependent kinase (CDK) that plays a major role in controlling the activities of proteins in the course of the cell cycle.

TLS Online TPP Program

#Id: 1535

#Unit 2. Cellular Organization

+TIPs, associate with growing plus ends and can link microtubules to other structures, such as membranes.

TLS Online TPP Program

#Id: 1536

#Unit 2. Cellular Organization

XMAP215 binds free tubulin subunits and delivers them to the plus end of a microtubule, dramatically accelerating polymerization.

TLS Online TPP Program

#Id: 1537

#Unit 2. Cellular Organization

Class V IF proteins 

Lamins