TLS Online TPP Program

#Id: 6807


The precursor RNA for the siRNA pathway is a longer dsRNA. As a consequence of this different initial substrate, Drosha is not needed for the generation of siRNAs. Cleavage by Dicer is still required, however, and again generates a suitable 21- to 22-nucleotide RNA for incorporation into RISC.

#Unit 3. Fundamental Processes #mRNA stability, transport, CRISPR, miRNA & siRNA #Part B Pointers