TLS Online TPP Program

#Id: 8592

#Unit 2. Cellular Organization

During telophase, de-phosphorylation by specific phosphatases promotes lamin reassembly, which is critical to re-formation of a nuclear envelope around the daughter chromosomes.

TLS Online TPP Program

#Id: 8593

#Unit 2. Cellular Organization

Laminopathies 

Mutation in lamin A

TLS Online TPP Program

#Id: 8594

#Unit 2. Cellular Organization

Emery-Dreifuss muscular dystrophy (EDMD)

mutations in emerin, a nesprin and a SUN protein

TLS Online TPP Program

#Id: 8595

#Unit 2. Cellular Organization

Mutations in lamin A 

cause progeria accelerated aging, such as Hutchison-Gilford progeria (“prematurely old”)

TLS Online TPP Program

#Id: 8596

#Unit 2. Cellular Organization

Septins 

GTP-binding proteins 

serve as an additional filament system in all eukaryotes except terrestrial plants. 

TLS Online TPP Program

#Id: 8597

#Unit 2. Cellular Organization

Septins assemble into nonpolar filaments that form rings and cagelike structures, or recruit and organize the actin and microtubule cytoskeletons.