Su(var) mutations lie in genes whose products are needed for the formation of heterochromatin such as HDAC, HMT.

TLS Online TPP Program

#Id: 7458

#Unit 5. Developmental Biology

The binding of ammonia to the sensor domain of DhkC leads to the activation of its histidine kinase activity and to the autophosphorylation of a DhkC histidine residue.

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#Id: 7459

#Unit 5. Developmental Biology

The phosphoryl group is transferred,  From histidine residue of DhkC  aspartate of DhkC histidine in phospho-transfer intermediate RdeA aspartate of RR of RegA

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#Id: 7460

#Unit 5. Developmental Biology

Ammonia inhibits PKA by indirectly activating cAMP hydrolysis via DhkC-RdeA mediated phosphorylation of RegA.

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#Id: 7461

#Unit 5. Developmental Biology

Binding of Spore differentiation factor 2 activates the histidine phosphatase activity of DhkA (histidine phosphatase A)

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#Id: 7462

#Unit 5. Developmental Biology

Histidine phosphatase activity of DhkA causes inactivation of RegA, the accumulation of cAMP and PKA activation, causes spore maturation.

TLS Online TPP Program

#Id: 7463

#Unit 5. Developmental Biology