TLS Online TPP Program

#Id: 8920

#Unit 2. Cellular Organization

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.

TLS Online TPP Program

#Id: 8921

#Unit 2. Cellular Organization

At the same time, Plk1 phosphorylates the Rho-GAP component, to form an active Centralspindlin-Ect2 complex. 

TLS Online TPP Program

#Id: 8922

#Unit 2. Cellular Organization

Centralspindlin-Ect2 complex catalyzes activation of RhoA, leading to cleavage furrow formation and division of the cytoplasm to form two completely separate cells.

TLS Online TPP Program

#Id: 8923

#Unit 2. Cellular Organization

Surveillance mechanisms known as checkpoint pathways responsible for the extraordinarily high fidelity of cell division, ensuring that each daughter cell receives the correct number of accurately replicated chromosomes

TLS Online TPP Program

#Id: 8924

#Unit 2. Cellular Organization

DNA damage response system

halts cell cycle progression and

recruits DNA repair machinery

when DNA is compromised

TLS Online TPP Program

#Id: 8925

#Unit 2. Cellular Organization

The protein kinases DNA-PK, ATM, and ATR are activated at sites of damaged DNA