A dedicated protein (a special elongation factor) named SELB in complex with GTP is required to deliver Sec–tRNASec to the ribosome. SELB ∙ GTP ∙ Sec–tRNASec reads the UGA codon as Sec rather than “Stop,” provided that the ribosomally bound
mRNA has a hairpin loop on the 3′ side of the UGA specifying Sec.
#Unit 3. Fundamental Processes#Prokaryotic Translation#Part B Pointers