#Id: 1764
#Unit 4. Cell Communication and Cell Signaling
Self antigens are not uncommon in the periphery, Two factors contribute to this: a. not all self a. antigens are expressed in the central lymphoid organs where negative selection occurs
b. there is a threshold requirement for affinity to self antigens before clonal deletion is triggered, allowing some weakly self-reactive clones to survive the weeding-out process.