Nurturing Life Sciences
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#Unit 2. Cellular Organization
A point mutation that affects a restriction site is detected by a difference in restriction fragment lengths.
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RFLPs and SNPs can be the basis for linkage maps and are useful for establishing parent–offspring relationships.
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Sections of DNA that are conserved among species can be identified by performing a zoo blot. We use short fragments from the region as labeled probes to test for homologous DNA from a variety of species by Southern blotting.
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When pairs of human 23 and mouse 20 homologs are compared, the genes located on either side also tend to be homologs. This relationship is called synteny
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Synteny provides a framework in which conservation of homologous genes and gene order is identified between genomes of different species