#Id: 3986
#Unit 2. Cellular Organization
Addition of a topoisomerase greatly facilitates nucleosome association with cccDNA.
When a topoisomerase is present during nucleosome assembly, it cannot act on the DNA bound to the nucleosome. Instead, the topoisomerase relaxes the DNA not included in nucleosomes, reducing the positive superhelical density in these regions by decreasing the linking number.
