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TLS Online TPP Program

#Id: 7206

IFN- ¥ has been shown to induce expression of the class II transcriptional activator (CIITA). 

#Unit 5. Developmental Biology #Major histocompatibility complex #Part B Pointers
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TLS Online TPP Program

#Id: 429

#Unit 2. Cellular Organization

Mononucleosomes typically have 200 bp DNA. End-trimming reduces the length of DNA first to 165 bp and then generates core particles with 146 bp.
TLS Online TPP Program

#Id: 430

#Unit 2. Cellular Organization

Mnase digestion result on centrifugation and electrophoresis
TLS Online TPP Program

#Id: 431

#Unit 2. Cellular Organization

Core DNA has an invariant length of 146 bp the minimum length of DNA needed to form a stable monomeric nucleosome, and is relatively resistant to digestion by nucleases.
TLS Online TPP Program

#Id: 432

#Unit 2. Cellular Organization

Core DNA invariant length of 146 bp contains core and linker histones so Mnase cuts after H1 binding site. 
TLS Online TPP Program

#Id: 433

#Unit 2. Cellular Organization

The nucleosome is a disc with DNA organized into 12/3 turns around the surface.
TLS Online TPP Program

#Id: 434

#Unit 2. Cellular Organization

The nucleosome is a disc of 11 nm diameter and 6 nm height. 2πrh is surface are and πr2h is volume of nucleosome