T1 cells are mIgMhi, mIgD -/lo, CD21-, CD23-, CD24+, and CD93+. 

T2 cells differ from T1 cells in having higher levels of mIgD and in expressing CD21 and CD23. 

TLS Online TPP Program

#Id: 7463

#Unit 5. Developmental Biology

TLS Online TPP Program

#Id: 7464

#Unit 5. Developmental Biology

In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA

TLS Online TPP Program

#Id: 7465

#Unit 5. Developmental Biology

Secreted GABA then acts on prestalk cells to induce the cell-surface exposure of the serine protease domain of the ABC transporter TagC.

TLS Online TPP Program

#Id: 7466

#Unit 5. Developmental Biology

GABA acts on prespore cells to induce secretion of AcbA.

TLS Online TPP Program

#Id: 7467

#Unit 5. Developmental Biology

AcbA is cleaved by the TagC protease to produce the peptide SDF-2.

TLS Online TPP Program

#Id: 7468

#Unit 5. Developmental Biology

SDF-2 activates the histidine phosphatase activity of DhkA, which induces spore encapsulation.