As cells enter into the S phase of the cell cycle, two kinases, CDK and DDK, are activated.  DDK phosphorylates loaded Mcm2-7 helicase, and CDK phosphorylates Sld2 and Sld3.Phosphorylated Sld2 and Sld3 bind to Dpb11, and together these proteins facilitate binding of the helicase-activating proteins, Cdc45 and GINS, to the helicase.  

TLS Online TPP Program

#Id: 8487

#Unit 1. Structure and Function of Biomolecules

Co and N atoms of the peptide grouping are both in planar sp2 hybridization and the Co and O atoms are linked by a p bond, leaving the nitrogen with a lone pair of electrons in a 2p orbital.

TLS Online TPP Program

#Id: 8488

#Unit 1. Structure and Function of Biomolecules

TLS Online TPP Program

#Id: 8489

#Unit 1. Structure and Function of Biomolecules

TLS Online TPP Program

#Id: 8490

#Unit 1. Structure and Function of Biomolecules

The coplanar relationship of the atoms in the amide group is highlighted as an imaginary

shaded plane lying between two successive a-carbon atoms in the peptide backbone.

TLS Online TPP Program

#Id: 8491

#Unit 1. Structure and Function of Biomolecules

The peptide bond is estimated to have 40% double bond character

TLS Online TPP Program

#Id: 8492

#Unit 1. Structure and Function of Biomolecules