As cells enter into the S phase of the cell cycle, two kinases, CDK and DDK, are activated.  DDK phosphorylates loaded Mcm2-7 helicase, and CDK phosphorylates Sld2 and Sld3.Phosphorylated Sld2 and Sld3 bind to Dpb11, and together these proteins facilitate binding of the helicase-activating proteins, Cdc45 and GINS, to the helicase.  

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#Unit 5. Developmental Biology

When Gurken binds to Torpedo, the terminal follicle cells differentiate into posterior follicle cells and synthesize a molecule that activates protein kinase A in the egg.

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#Unit 3. Fundamental Processes

Arsenic induces polyadenylation of canonical histone H3.1 mRNA in vivo

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#Unit 6. System Physiology – Plant

When the CCA1 gene is mutated so that no functional protein is produced, circadian and phytochrome regulation of four genes, including LHCB, is affected.

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#Unit 4. Cell Communication and Cell Signaling

Constitutively active Raf kinase

a glutamic acid substitution for the valine at position 600

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#Id: 742

#Unit 3. Fundamental Processes

The phosphodiester bond is formed in an SN2 reaction in which the hydroxyl group at the 3’ end of the primer strand attacks the a-phosphoryl group of the incoming nucleoside triphosphate.