TLS Online TPP Program

#Id: 8908

#Unit 2. Cellular Organization

Phosphatase is recruited to centromeric by the Shugoshin family of proteins

TLS Online TPP Program

#Id: 8909

#Unit 2. Cellular Organization

Separase cleaves centromeric cohesin, triggering the onset of anaphase, releasing the sister chromatids

TLS Online TPP Program

#Id: 8910

#Unit 2. Cellular Organization

Before anaphase Separase is inhibited by the binding of the protein securin and Mitotic CDKs.

TLS Online TPP Program

#Id: 8911

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8912

#Unit 2. Cellular Organization

When all the kinetochores have properly attached to spindle microtubules, APC/CCdc20 directs ubiquitinylation of securin and mitotic cyclins

TLS Online TPP Program

#Id: 8913

#Unit 2. Cellular Organization

APC/CCdc²⁰ is inhibited by a checkpoint pathway that ensures that anaphase is not initiated until all chromosomes have achieved proper attachment to the mitotic apparatus.