The phosphoryl group is transferred,  From histidine residue of DhkC  aspartate of DhkC histidine in phospho-transfer intermediate RdeA aspartate of RR of RegA

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#Unit 4. Cell Communication and Cell Signaling

The central player in the “canonical” Wnt intracellular signal transduction pathway is called β-catenin.

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Homologs

β-catenin in vertebrates =Armadillo in Drosophila.

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#Unit 4. Cell Communication and Cell Signaling

“canonical” Wnt signaling pathway uses a second transmembrane protein, LRP that associates with Frizzled in a Wnt signal– dependent manner.

 

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#Unit 4. Cell Communication and Cell Signaling

Homologs

LRP in vertebrates = Arrow in Drosophila.

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#Unit 4. Cell Communication and Cell Signaling

In the absence of Wnts,

β-catenin is bound in a complex with Axin (a scaffold protein), APC, and kinases CK1 and GSK3.

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Kinases CK1 and GSK3,

sequentially phosphorylate β-catenin at multiple serine and threonine residues.