#Id: 3032
#Unit 3. Fundamental Processes
DNA polymerase III holoenzyme assembles in stages, generating an enzyme complex that synthesizes the DNA of both new strands.\
Binding to DNA changes the conformation of the site on B that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase.
First the clamp loader uses hydrolysis ofATPtobindbeta subunits to a template primercomplex.
Binding to DNA changes the conformation of the site on B that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase.
tau. dimer binds to the core polymerase, and provides a dimerization function thatbinds a second core polymerase (associated with another B2