TLS Online TPP Program

#Id: 6557

#Unit 7. System Physiology – Animal

Human preproglucagon is a 179-amino-acid protein that is found in pancreatic A cells, in L cells in the lower GIT, and in the brain

TLS Online TPP Program

#Id: 6558

#Unit 7. System Physiology – Animal

In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

TLS Online TPP Program

#Id: 6559

#Unit 7. System Physiology – Animal

In L cells, preproglucagon is processed primarily to glicentin, & glucagon-like polypeptides 1 and 2. Some oxyntomodulin is also formed

TLS Online TPP Program

#Id: 6560

#Unit 7. System Physiology – Animal

In both A and L cells, residual glicentin-related polypeptide (GRPP) is left

TLS Online TPP Program

#Id: 6561

#Unit 7. System Physiology – Animal

GLP-1 is processed further by removal of its amino-terminal amino acid residues and the product, GLP-1 (7–36), is a potent stimulator of insulin secretion

TLS Online TPP Program

#Id: 6562

#Unit 7. System Physiology – Animal

Glucagon is glycogenolytic, gluconeogenic, lipolytic, and ketogenic