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TLS Online TPP Program

#Id: 7697

                                                                 Greek Key Motif

Made-up of beta-sheets

Four adjacent antiparallel strands linked by loops

Three anti-parallel beta sheets are connected 3 loops

The pattern is similar to ornamental pattern used I ancient Greece, therefore called as Greek Key motif


#Unit 1. Structure and Function of Biomolecules #atom #Part B Pointers
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TLS Online TPP Program

#Id: 7939

#Unit 2. Cellular Organization

The GTPase cycle analogous to the GTP hydrolysis coupled to the initiation of translation on the ribosome.
TLS Online TPP Program

#Id: 7940

#Unit 2. Cellular Organization

Once the SRP and its receptor have targeted a ribosome synthesizing a secretory protein to the ER membrane, the ribosome and nascent polypeptide chain are rapidly transferred to the translocon.
TLS Online TPP Program

#Id: 7941

#Unit 2. Cellular Organization

The translocon was first identified through mutations in the yeast gene encoding a protein called Sec61α
TLS Online TPP Program

#Id: 7942

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 7943

#Unit 2. Cellular Organization

Classes of ER membrane proteins
TLS Online TPP Program

#Id: 7944

#Unit 2. Cellular Organization

Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles