H bonding i-i+3, i+1 in BS while i+2 in below LHH which virtually not allowed region

for most of amino acid except Gly that is why Gly is most conserved in type II B turns

                                                                Type II β turn

TLS Online TPP Program

#Id: 10012

#Unit 4. Cell Communication and Cell Signaling

Ptc contains 12 TM α helices and structurally similar

to the Niemann-Pick C1 protein, a cholesterol transporting member of the ABC superfamily

TLS Online TPP Program

#Id: 10013

#Unit 4. Cell Communication and Cell Signaling

In the absence of Hh,

Ptc inhibits Smoothened and then degraded in proteasomes

TLS Online TPP Program

#Id: 10014

#Unit 4. Cell Communication and Cell Signaling

Transcription Factor

zinc-finger transcription factor Cubitis interruptus

TLS Online TPP Program

#Id: 10015

#Unit 4. Cell Communication and Cell Signaling

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 10016

#Unit 4. Cell Communication and Cell Signaling

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).

TLS Online TPP Program

#Id: 10017

#Unit 4. Cell Communication and Cell Signaling

In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.