Nurturing Life Sciences
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#Id: 1054
#Unit 5. Developmental Biology
Hox12 and Hox13 paralogues specify the autopod.
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AER of the fin bud changes into an apical ectodermal fold that promotes fin ray development.
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Limb field represents a “harmonious equipotent system” wherein a cell can be instructed to form any part of the limb.
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The gene encoding Tbx5 is transcribed in limb fields of the forelimbs.
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The genes encoding Islet1, Tbx4, and Pitx1 are expressed in presumptive hindlimbs.
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Tbx stands for “T-box,” a specific DNA-binding domain.