FRET allows the detection of position of sigma relative to a site on the DNA to be measured with using separation techniques that might displace sigma from the core enzyme

 

TLS Online TPP Program

#Id: 6921

#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm

Wolf– Hirschhorn syndrome- Deletion on 4, short arm

Williams– Beuren syndrome - Deletion on 7, long arm

Prader– Willi syndrome- Deletion on 15 long arm 

TLS Online TPP Program

#Id: 6922

#Unit 8. Inheritance Biology

Deletion of a number of pairs that is not evenly divisible by three will lead to a frameshift mutation. 

TLS Online TPP Program

#Id: 6923

#Unit 8. Inheritance Biology

In an individual heterozygous for a deletion, the normal chromosome loops out during chromosome pairing in prophase I.

TLS Online TPP Program

#Id: 6924

#Unit 8. Inheritance Biology

Deletion includes the centromere, then the chromosome will not segregate in meiosis or mitosis and will usually be lost.

TLS Online TPP Program

#Id: 6925

#Unit 8. Inheritance Biology

Deletions are lethal in the homozygous state because all copies of any essential genes located in the deleted region are missing.

TLS Online TPP Program

#Id: 6926

#Unit 8. Inheritance Biology

Heterozygous condition may produce imbalances in the amounts of gene products similar to those produced by extra gene copies.