TLS Online TPP Program

#Id: 8368


Myosin V
Two heads but does not assemble into filaments
Large and processive
Function- Organelle transport

#Unit 2. Cellular Organization #MICROFILAMENTS #Part B Pointers
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TLS Online TPP Program

#Id: 354

#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA and NADH are potent allosteric inhibitors of the enzyme. 


TLS Online TPP Program

#Id: 355

#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA inhibits the transacetylase component whereas NADH inhibits the dihydrolipoyl dehydrogenase component. 

TLS Online TPP Program

#Id: 356

#Unit 1. Molecules and their Interaction Relevant to Biology

The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)

TLS Online TPP Program

#Id: 359

#Unit 1. Molecules and their Interaction Relevant to Biology

Eukaryotic cells have two isozymes of aconitase
The mitochondrial isozyme (convert citrate to isocitrate in the citric acid cycle)
The cytosolic isozyme 

TLS Online TPP Program

#Id: 360

#Unit 1. Molecules and their Interaction Relevant to Biology

The cytosolic isozymes has two distinct function, It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis

TLS Online TPP Program

#Id: 363

#Unit 1. Molecules and their Interaction Relevant to Biology

When cellular iron concentrations return to normal levels, IRP1 is converted to aconitase, and IRP2 undergoes proteolytic degradation, ending the low-iron response.