MICOS has an integral membrane protein subunit that homo-oligomerizes and bends the inner membrane to produce high curvature.

TLS Online TPP Program

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#Unit 1. Molecules and their Interaction Relevant to Biology

Pyruvate Carboxylase

a mitochondrial enzyme that requires the coenzyme biotin, converts the pyruvate to oxaloacetate

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#Unit 1. Molecules and their Interaction Relevant to Biology

The oxaloacetate is converted to PEP by phosphoenolpyruvate carboxykinase. This Mg2+ dependent reaction requires GTP as the phosphoryl group donor.

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#Unit 1. Molecules and their Interaction Relevant to Biology

Transketolase requires the cofactor thiamine pyrophosphate (TPP)

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#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA and NADH are potent allosteric inhibitors of the enzyme. 

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#Unit 1. Molecules and their Interaction Relevant to Biology

Acetyl-CoA inhibits the transacetylase component whereas NADH inhibits the dihydrolipoyl dehydrogenase component. 

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#Unit 1. Molecules and their Interaction Relevant to Biology

The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)