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TLS Online TPP Program

#Id: 7960

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.


#Unit 2. Cellular Organization #Interrupted Genes #Part A (Short Concepts)
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TLS Online TPP Program

#Id: 10010

#Unit 4. Cell Communication and Cell Signaling

Two membrane proteins, 
Smoothened (Smo) 
Patched (Ptc)
TLS Online TPP Program

#Id: 10011

#Unit 4. Cell Communication and Cell Signaling

Smo has seven TM α helices, is a member of the GPCR superfamily, and is related in sequence to the Fz.
TLS Online TPP Program

#Id: 10012

#Unit 4. Cell Communication and Cell Signaling

Ptc contains 12 TM α helices and structurally similar
to the Niemann-Pick C1 protein, a cholesterol transporting member of the ABC superfamily
TLS Online TPP Program

#Id: 10013

#Unit 4. Cell Communication and Cell Signaling

In the absence of Hh,
Ptc inhibits Smoothened and then degraded in proteasomes
TLS Online TPP Program

#Id: 10014

#Unit 4. Cell Communication and Cell Signaling

Transcription Factor
zinc-finger transcription factor Cubitis interruptus
TLS Online TPP Program

#Id: 10015

#Unit 4. Cell Communication and Cell Signaling

A cytosolic complex contains
kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU