While DnaA has a weak intrinsic activity that converts the ATP to ADP, this is enhanced by a factor termed Hda.

TLS Online TPP Program

#Id: 8410

#Unit 2. Cellular Organization

TN-C is the calcium-binding subunit, controls the

position of TM on the surface of an actin filament through the TN-I and TN-T subunits

TLS Online TPP Program

#Id: 8411

#Unit 2. Cellular Organization

In the absence of Ca2+, muscle is relaxed

TM blocks myosin’s interaction with F-actin

TLS Online TPP Program

#Id: 8412

#Unit 2. Cellular Organization

Binding of Ca2+ ions to TN-C

triggers movement of TM to a new position on the filament, thereby exposing the myosin-binding sites on actin.

TLS Online TPP Program

#Id: 8413

#Unit 2. Cellular Organization

Troponin C is closely related to the ubiquitous 

Ca2+-binding protein calmodulin

TLS Online TPP Program

#Id: 8414

#Unit 2. Cellular Organization

Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

TLS Online TPP Program

#Id: 8415

#Unit 2. Cellular Organization

Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene