The main MutS homologs in most eukaryotes are MSH2 (MutS homolog), MSH3, and MSH6.

TLS Online TPP Program

#Id: 8939

#Unit 2. Cellular Organization

checkpoint factors Bub1-Bub3, BubR1 and Mad2-C Together, these proteins form the mitotic checkpoint complex

TLS Online TPP Program

#Id: 8940

#Unit 2. Cellular Organization

Knl1 eliminating checkpoint protein binding sites at kinetochores. p31comet disassembles the MCC, allowing APC/Ccdc20 to degrade mitotic cyclins and securin to trigger anaphase.

TLS Online TPP Program

#Id: 8941

#Unit 2. Cellular Organization

Spindle position checkpoint pathway ensures that the nucleus is accurately partitioned between two daughter cells

TLS Online TPP Program

#Id: 8942

#Unit 2. Cellular Organization

In S. cerevisiae, during interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. 

TLS Online TPP Program

#Id: 8943

#Unit 2. Cellular Organization

Inactive Tem1-GDP associates with the spindle pole body nearest to the bud as soon as the mitotic spindle forms

TLS Online TPP Program

#Id: 8944

#Unit 2. Cellular Organization

If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.