The hMutb complex, a Msh2-Msh3 dimer, binds mismatched insertion/deletion/slippage loops, while the Msh2-Msh6 (hMuta) complex binds to single-base mismatches.

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.

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#Unit 4. Cell Communication and Cell Signaling

Movement of the GSVs to the plasma membrane is regulated by two monomeric GTP-binding proteins -RalA and Rab10

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#Unit 4. Cell Communication and Cell Signaling

Insulin receptor activates the PI-3 kinase/PKB pathway

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#Unit 4. Cell Communication and Cell Signaling

Active PKB, phosphorylates

and inhibits the GTP→GDP hydrolysis activity of two GAP

proteins - AS160 and RGC

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#Unit 4. Cell Communication and Cell Signaling

Phosphorylation causes the binding of AS160 to the 

14-3-3 protein that sequesters it in the cytosol away from its target Rab proteins

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#Unit 4. Cell Communication and Cell Signaling

In the basal state, 

GAPs inhibit RalA and Rab10 function by enhancing their rates of GTP hydrolysis