Nurturing Life Sciences
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#Unit 5. Developmental Biology
Sox17
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Another set of early genes activated by VegT encodes Nodal paracrine factors that instruct the cell layers above them to become mesoderm
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Nieuwkoop center
Dorsalmost vegetal cells of the blastula, which are capable of inducing the organizer dorsal vegetal cells can induce animal cells to become dorsal mesodermal tissue)
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The major candidate for the factor that forms the Nieuwkoop center was β-catenin (This multifunctional protein also proved to be a key player in the formation of the dorsal amphibian tissues)
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During first cleavage, GBP, Dsh, and Wnt11 are brought into the future dorsal section of the embryo protect β-catenin