Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

TLS Online TPP Program

#Id: 6033

#Unit 3. Fundamental Processes

Failure to remove a flap rapidly can have important consequences in regions of repeated sequences such as deletion and duplication

TLS Online TPP Program

#Id: 6034

#Unit 3. Fundamental Processes

Direct repeats can be displaced and misaligned with the template; palindromic sequences can form hairpins. These structures may change the number of repeats. The general importance of FEN1 is that it prevents flaps of DNA from generating structures that may cause deletions or duplications in the genome.

TLS Online TPP Program

#Id: 6035

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6097

#Unit 3. Fundamental Processes

The shifts of hydrogen atoms between the number 3 and number 4 positions of the pyrimidines and between the number 1 and number 6 positions of the purines change their base-pairing potential due to Tautomeris

TLS Online TPP Program

#Id: 6098

#Unit 3. Fundamental Processes

Tautomerism is most common spontaneous form of mutagenic event which causes transition during replication

TLS Online TPP Program

#Id: 6099

#Unit 3. Fundamental Processes

There are two kind of mutation 

1. Base substitution

2. Frameshift