Retromer

a coat protein complex specialized for endosome-to-TGN transport, recycle the M6P receptor to the TGN

TLS Online TPP Program

#Id: 1424

#Unit 4. Cell Communication and Cell Signaling

The α subunit of each integrin is the primary determinant of its extracellular ligand specificity.

TLS Online TPP Program

#Id: 1425

#Unit 4. Cell Communication and Cell Signaling

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 1426

#Unit 4. Cell Communication and Cell Signaling

I-domains also recognize CAMs on other cells,  ICAMs, VCAMs and participate in cell-cell adhesion.

TLS Online TPP Program

#Id: 1427

#Unit 4. Cell Communication and Cell Signaling

The non-I-domain α subunits recognize RGD motif.

TLS Online TPP Program

#Id: 1428

#Unit 4. Cell Communication and Cell Signaling

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.

TLS Online TPP Program

#Id: 1429

#Unit 4. Cell Communication and Cell Signaling

Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.