TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 

ε-amino group of a specific lysine of α-tubulin

Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)

TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8524

#Unit 2. Cellular Organization

Detyrosylation 

tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits. 

TLS Online TPP Program

#Id: 8525

#Unit 2. Cellular Organization

Detyrosylated microtubules are more stable, because they are more resistant to depolymerization by kinesin-13 and related proteins.

TLS Online TPP Program

#Id: 8526

#Unit 2. Cellular Organization

Polyglutamylation and polyglycylation are likely mutually exclusive, so they would not normally occur at the same time & both can enhance microtubule stability,

TLS Online TPP Program

#Id: 8527

#Unit 2. Cellular Organization

Kinesin-1 associates preferentially with detyrosylated and acetylated microtubules.