TLS Online TPP Program

#Id: 4772

#Unit 5. Developmental Biology

The TBX-35 transcription factor activates mesodermal genes in the MS cell, including pha-4 in the pharynx and hlh-1 in muscles.

TLS Online TPP Program

#Id: 4773

#Unit 5. Developmental Biology

TBX-35 inhibits pal-1 gene expression, preventing the MS cell from acquiring the C-blastomere fates.

TLS Online TPP Program

#Id: 4774

#Unit 5. Developmental Biology

At the 4-cell stage, the EMS cell requires a signal from its neighbor (and sister cell), the P2 blastomere.

TLS Online TPP Program

#Id: 4775

#Unit 5. Developmental Biology

The P2 cell produces the MOM-2 protein, a C. elegans Wnt protein.

TLS Online TPP Program

#Id: 4776

#Unit 5. Developmental Biology

MOM-2 is received in the EMS cell by the MOM-5 protein, a C. elegans protein Frizzled.

TLS Online TPP Program

#Id: 4777

#Unit 5. Developmental Biology

Wnt signaling cascade is to downregulate the expression of the pop-1 gene in the EMS daughter destined to become the E cell.