The rate of addition of monomers is given by

rate constant kon (M–1 sec–1 )

The rate of loss is given by koff (sec–1)

TLS Online TPP Program

#Id: 5478

#Unit 7. System Physiology – Animal

TLS Online TPP Program

#Id: 5479

#Unit 7. System Physiology – Animal

Ca2+ uptake into the terminal causes release of the neurotransmitter acetylcholine (ACh), which has been previously synthesized and stored in synaptic vesicles.

TLS Online TPP Program

#Id: 5480

#Unit 7. System Physiology – Animal

ACh is formed from acetyl coenzyme A (acetyl CoA) and choline by the action of the enzyme choline acetyltransferase

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#Id: 5481

#Unit 7. System Physiology – Animal

ACh diffuses across the synaptic cleft to the postsynaptic Membrane of motor end plate, which contains nicotinic receptors

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#Id: 5482

#Unit 7. System Physiology – Animal

The nicotinic receptor for ACh is an example of a ligand-gated ion channel

TLS Online TPP Program

#Id: 5483

#Unit 7. System Physiology – Animal

ACh is degraded to choline and acetate by acetylcholinesterase (AChE) on the motor end plate