Treadmilling

Because the critical concentrations for the two ends are different, at steady state the free ATP–G-actin will be intermediate between Cc+ and Cc - , so the (+)end will grow and the (-)end will lose subunits.

TLS Online TPP Program

#Id: 410

#Unit 2. Cellular Organization

H3.3 is available for assembly at any time in the cell cycle, and is incorporated at sites of active transcription, where nucleosomes become disrupted.

TLS Online TPP Program

#Id: 411

#Unit 2. Cellular Organization

H3.3 is often referred to as a “replacement” histone.

TLS Online TPP Program

#Id: 412

#Unit 2. Cellular Organization

The H2A variants are the largest and most diverse family of core histone variants.

TLS Online TPP Program

#Id: 413

#Unit 2. Cellular Organization

H2AX is normally present in only 10%–15% of the nucleosomes in multicellular eukaryotes

TLS Online TPP Program

#Id: 414

#Unit 2. Cellular Organization

H2AX subtype is has a C-terminal tail that is distinct from the canonical H2A, characterized by a SQEL/Y motif at the end.

TLS Online TPP Program

#Id: 415

#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair