To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 9039

#Unit 4. Cell Communication and Cell Signaling

The tighter the binding of a ligand to its receptor,the lower the concentration of ligand needed to achieve binding to 50 percent of the receptors.

TLS Online TPP Program

#Id: 9040

#Unit 4. Cell Communication and Cell Signaling

GPCR function as GEFs for heterotrimeric G protein.

TLS Online TPP Program

#Id: 9041

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9042

#Unit 4. Cell Communication and Cell Signaling

Heterotrimeric G proteins directly bind to and are activated by G protein coupled receptors.

TLS Online TPP Program

#Id: 9043

#Unit 4. Cell Communication and Cell Signaling

Switching mechanism of monomeric G proteins 

“On” state, switch I and switch II, are bound to the terminal γ phosphate of GTP with the backbone amide groups of conserved T & G.

TLS Online TPP Program

#Id: 9044

#Unit 4. Cell Communication and Cell Signaling