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#Unit 3. Fundamental Processes
Translesion synthesis is catalyzed by a specialized class of DNA polymerases that synthesize DNA directly across the site of the damage. In E. coli, DNA Pol IV (DinB) or DNA Pol V (a complex of the proteins UmuC and UmuD’) performs translesion synthesis. DinB and UmuC are members of a distinct family of DNA polymerases found in many organisms known as the Y family of DNA
polymerases. There are five translesion polymerases known in humans, four of which belong to the Y family.
